1. Weeks R, Mehta S, and Zhang J. Genetically encodable biosensors for Ras activity. RSC Chem Biol. 2024; 5: 312-320. PMID 38576721
  2. Frei MS, Mehta S, and Zhang J. Next-generation genetically encoded fluorescent biosensors illuminate cell signaling and metabolism. Annu Rev Biophys. 2024; 53. PMID 38346245
  3. Hardy JC, Pool EH, Bruystens JGH, Zhou X, Li Q, Zhou DR, Palay M, Tan G, Chen L, Choi JLC, Lee HN, Strack S, Wang D, Taylor SS, Mehta S, and Zhang J. Molecular determinants and signaling effects of PKA RIα phase separation. Mol Cell. 2024; 84(8): 1570-1584.e7. PMID 38537638
  4. Lyons AC, Mehta S, and Zhang J. Fluorescent biosensors illuminate the spatial regulation of cell signaling across scales. Biochem J. 2023; 480(20): 1693–1717. PMID 37903110
  5. Elias R, Zhu Y, Su Q, Ghirlando R, Zhang J, and Deshmukh L. Reversible phase separation of ESCRT protein ALIX through tyrosine phosphorylation. Sci Adv. 2023; 9(28): eadg3913. PMID 37450591
  6. Posner C, Mehta S, and Zhang J. Fluorescent biosensor imaging meets deterministic mathematical modelling: quantitative investigation of signalling compartmentalization. J Physiol. 2023; 601(19): 4227-4241. PMID 37747358
  7. Greenwald E*, Posner C*, Bharath A, Lyons A, Salmeron C, Sriram K, Wiley SZ, Insel PA†, and Zhang J†. GPCR signaling measurement and drug profiling with an automated live-cell microscopy system. *Equal contribution. †Co-corresponding authors. ACS Sensors. 2023; 8(1): 19-27. PMID 36602887
  8. Schmitt DL, Mehta S, Zhang J. Study of spatiotemporal regulation of kinase signaling using genetically encodable molecular tools. Curr Opin Chem Biol. 2022; 71:102224. PMID 36347198
  9. Kwon Y, Mehta S, Clark M, Walter G, Zhong Y, Lee HN, Sunahara RK, Zhang J. Non-canonical beta-adrenergic activation of ERK at endosomes. Nature. 2022; 611(7934): 173-179. PMID 36289326
  10. Kwon Y, Kim DH, Jeong MG, Hong MT, Park S, Chang Y, Zhou K, Park SY, Zhang J, Ryu SH. Dimerization of beta2-adrenergic receptor is responsible for the constitutive activity subjected to inverse agonism. Cell Chem Biol. 2022; 29(10): 1532-1540. PMID 36167077
  11. Hashizume R, Fujii H, Mehta S, Ota K, Qian Y, Zhu W, Drobizhev M, Nasu Y, Zhang J, Bito H, Campbell RE. A genetically encoded far-red fluorescent calcium ion biosensor derived from a biliverdin-binding protein. Protein Sci. 2022; 31(10): e4440. PMID 36173169
  12. Weeks R, Zhou X, Yuan TL, Zhang J. Fluorescent biosensor for measuring Ras activity in living cells. J Am Chem Soc. 2022; 144(38): 17432-17440. PMID 36122391
  13. Schmitt DL, Curtis SD, Lyons AC, Zhang JF, Chen M, He CY, Mehta S, Shaw RJ, Zhang J. Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter. Nat Commun. 2022; 13: 3856. PMID 35790710
  14. Zhong Y, Zhou X, Guan KL, Zhang J. Rheb regulates nuclear mTORC1 activity independent of farnesylation. Cell Chem Biol. 2022; 29(6): 1037-1045.e4. PMID 35294906
  15. Zhou X, Mehta S, Zhang J. AktAR and Akt-STOPS: Genetically encodable molecular tools to visualize and perturb Akt kinase activity at different subcellular locations in living cells. Current Protocols.. 2022; 2: e416. PMID 35532280
  16. Mehta S and Zhang J. Liquid-liquid phase separation drives cellular function and dysfunction in cancer. Nat Rev Cancer. 2022; 22(4): 239-252. PMID 35149762
  17. Hardy JC, Mehta S, Zhang J. Measuring spatiotemporal cAMP dynamics within an endogenous signaling compartment using FluoSTEP-ICUE. Methods Mol Biol. 2022; 2483: 351-366. PMID 35286687.
  18. Zhang JF, Mehta S, Zhang J. Protocol for reading and imaging live-cell PKA activity using ExRai-AKAR2. STAR Protoc. 2022; 3(1): 101071. PMID 35036953
  19. Chen M, Sun T, Zhou X, Zhang J. A sensitive fluorescent Akt biosensor reveals lysosome-selective regulation of lipid second messengers and kinase activity. ACS Cent Sci. 2021; 7(12): 2009-2020. PMID 34963894
  20. Valentine JM, Ahmadian M, Keinan O, Abu-Odeh M, Zhao P, Zhou X, Keller MP, Gao H, Yu RT, Liddle C, Downes M, Zhang J, Lusis AJ, Attie AD, Evans RM, Rydén M, Saltiel AR. β3-adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity. J Clin Invest. 2022; 132(2): e153357. PMID 34847077
  21. Lee YU, Posner C, Nie Z, Zhao J, Li S, Bopp SE, Wisna GBM, Ha J, Song C, Zhang J, Yang S, Zhang X, Liu Z. Organic hyperbolic material assisted illumination nanoscopy. Adv Sci. 2021; 8(22): 2102330. PMC8596098
  22. Zhang JZ, Mehta S, Zhang J. Liquid-liquid phase separation: a principal organizer of the cell’s biochemical activity architecture. Trends Pharmacol Sci. 2021; 42(10): 845-856. PMID 34373114
  23. Su Q, Mehta S, Zhang J. Liquid-liquid phase separation: orchestrating cell signaling through time and space. Mol Cell. 2021; 81(20): 4137-4146. PMID 34619090
  24. Lin W, Mo GCH, Mehta S, Zhang J. DrFLINC contextualizes super-resolution activity imaging. J Am Chem Soc. 2021; 143(37): 14951-14955. PMID 34516108
  25. Zhang JZ, Tenner B, Mehta S, Zhang J. Protocol for using Fluorescent Sensors Targeted to Endogenous Proteins (FluoSTEPs) to measure microdomain-specific signaling events. STAR Protoc. 2021; 2(3): 100693. PMID 34467224
  26. Liu L, Limsakul P, Meng X, Huang Y, Harrison RES, Huang TS, Shi Y, Yu Y, Charupanit K, Zhong S, Lu S, Zhang J, Chien S, Sun J, Wang Y. Integration of FRET and sequencing to engineer kinase biosensors from mammalian cell libraries. Nat Commun. 2021; 12(1): 5031. PMID 34413312
  27. Keyes J, Mehta S, Zhang J. Strategies for multiplexed biosensor imaging to study intracellular signaling networks. Methods Mol Biol. 2021; 2350: 1-20. PMID 34331275
  28. Abu-Odeh M, Zhang Y, Reilly SM, Ebadat N, Keinan O, Valentine JM, Hafezi-Bakhtiari M, Ashayer H, Mamoun L, Zhou X, Zhang J, Yu RT, Dai Y, Liddle C, Downes M, Evans RM, Kliewer SA, Mangelsdorf DJ, Saltiel AR. FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes. Cell Rep. 2021; 35(13): 109331. PMID 34192547
  29. Ahn SH, Qin S, Zhang JZ, McCammon JA, Zhang J, and Zhou HX. Characterizing protein kinase A (PKA) subunits as macromolecular regulators of PKA RIα liquid-liquid phase separation. J Chem Phys. 2021; 154(22): 221101. PMID 34241191
  30. Bohrer CH, Yang X, Thakur S, Weng X, Tenner B, McQuillen R, Ross B, Wooten M, Chen X, Zhang J, Roberts E, Lakadamyali M, Xiao J. A pairwise Distance Distribution Correction (DDC) algorithm to eliminate blinking-caused artifacts in super-resolution microscopy. Nat Methods. 2021; 18(6): 669-677. PMID 34059826.
  31. Tenner B*, Zhang JZ*, Kwon Y, Pessino V, Feng S, Huang B, Mehta S†, Zhang J†. FluoSTEPs: Fluorescent biosensors for monitoring compartmentalized signaling within endogenous microdomains. *Equal contribution. †Co-corresponding authors. Sci Adv. 2021; 7(21): eabe4091. PMID 34020947.
  32. Mehta S and Zhang J. Biochemical activity architectures visualized – Using genetically encoded fluorescent biosensors to map the spatial boundaries of signaling compartments. Acc Chem Res. 2021; 54(10): 2409-2420. PMID 33949851
  33. Lei Y*, Zhang J*, Schiavon CR, He M, Chen L, Shen H, Zhang Y, Yin Q, Cho Y, Andrade L, Shadel GS, Hepokoski M, Lei T, Wang H, Zhang J, Yuan JXJ, Malhotra A, Manor U†, Wang S†, Yuan Z†, Shyy JY†. SARS-CoV-2 spike protein impairs endothelial function via downregulation of ACE 2. *Equal contribution. †Co-corresponding authors. Circ Res. 2021; 128(9): 1323-1326. PMID 33784827
  34. Roebroek T, Vandenberg W, Sipieter F, Hugelier S, Stove C, Zhang J, Dedecker P. Simultaneous readout of multiple FRET pairs using photochromism. Nat Commun. 2021; 12(1): 2005. PMID 33790271
  35. Lee YU, Zhao J, Ma Q, Khorashad LK, Posner C, Li G, Wisna GBM, Burns Z, Zhang J, Liu Z. Metamaterial assisted illumination nanoscopy via random super-resolution speckles. Nat Commun. 2021; 12(1): 1559. PMID 33692354
  36. Lee YU, Li S, Bopp SE, Zhao J, Nie Z, Posner C, Yang S, Zhang X, Zhang J, Liu Z. Unprecedented fluorophore photostability enabled by low-loss organic hyperbolic materials. Adv Mater. 2021; 33(9): e2006496. PMID 33506542
  37. Lee YU, Posner C, Zhao J, Zhang J, Liu Z. Imaging of cell morphology changes via metamaterial-assisted photobleaching microscopy. Nano Lett. 2021; 21(4): 1716-1721. PMID 33576637
  38. Fong MY, Yan W, Ghassemian M, Wu X, Zhou X, Cao M, Jiang L, Wang J, Liu X, Zhang J, Wang SE. Cancer-secreted miRNAs regulate amino-acid-induced mTORC1 signaling and fibroblast protein synthesis. EMBO Rep. 2021; 22(2): e51239. PMID 33345445
  39. Zhang JF*, Liu B*, Hong I*, Mo A, Roth RH, Tenner B, Lin W, Zhang JZ, Molina RS, Drobizhev M, Hughes TE, Tian L, Huganir RH†, Mehta S†, Zhang J†. An ultrasensitive biosensor for high-resolution kinase activity imaging in awake mice. *Equal contribution. †Co-corresponding authors. Nat Chem Biol. 2021; 17(1): 39-46. PMID 32989297
  40. Zhang JF, Mehta S, Zhang J. Signaling microdomains in the spotlight: visualizing compartmentalized signaling using genetically encoded fluorescent biosensors. Annu Rev Pharmacol Toxicol. 2021; 61: 587-608. PMID 3341579
  41. Zhou X, Zhong Y, Molinar-Inglis O, Kunkel MT, Chen M, Sun T, Zhang J, Shyy JY, Trejo J, Newton AC, Zhang J. Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus. Nat Commun. 2020; 11(1): 6088. PMID 33257668
  42. Tenner B, Getz M, Ross B, Ohadi D, Bohrer CH, Greenwald E, Mehta S, Xiao J, Rangamani P†, Zhang J†. Spatially compartmentalized phase regulation of a Ca2+-cAMP-PKA oscillatory circuit. †Co-corresponding authors. eLife. 2020; 9: e55013. PMID 33201801
  43. Zhou X, Mehta S, Zhang J. Genetically encodable fluorescent biosensors light up signaling networks. Trends Biochem Sci. 2020; 45(10): 889-905. PMID 32660810
  44. Zhang JZ, Lu TW, Stolerman LM, Tenner B, Yang JR, Zhang JF, Falcke M, Rangamani P, Taylor SS, Mehta S, Zhang J. Phase separation of a regulatory subunit of protein kinase A controls cAMP compartmentation and oncogenic signaling. Cell. 2020; 182(6): 1531-1544. PMID 32846158
  45. Zhang JZ, Nguyen AH, Miyamoto S, Brown JH, McCulloch, AD, Zhang J. Histamine-induced biphasic activation of RhoA allows for persistent RhoA signaling. PLoS Biol. 2020; 18(9): e3000866. PMID 32881857
  46. Lee YU, Zhao J, Mo GCH, Li S, Li G, Ma Q, Yang Q, Lal R, Zhang J, Liu Z. Metamaterial-assisted photobleaching microscopy with nanometer scale axial Resolution. Nano Lett. 2020; 20(8): 6038. PMID 32597659
  47. Keyes J, Ganesan A, Molinar-Inglis O, Hamidzadeh A, Zhang JF, Ling M, Trejo J, Levchenko A, Zhang J. Signaling diversity enabled by Rap1-regulated plasma membrane ERK with distinct temporal dynamics. eLife. 2020; 9: e57410. PMID 32452765
  48. Mo GCH, Posner C, Rodriguez E, Sun T, Zhang J. A rationally enhanced red fluorescent protein expands the utility of FRET biosensors. Nat Commun. 2020; 11(1): 1848. PMID 32296061
  49. Lee HN, Mehta S, Zhang J. Recent advances in the use of genetically encodable optical tools to elicit and monitor signaling events. Curr Opin Cell Biol. 2020; 63: 114-124. PMID 32058267
  50. Wijaya J, Vo BT, Liu J, Xu B, Wu G, Wang Y, Peng J, Zhang J, Janke LJ, Orr BA, Yu J, Roussel MF, Schuetz JD. An ABC transporter drives medulloblastoma pathogenesis by regulating Sonic Hedgehog signaling. Cancer Res. 2020; 80(7): 1524-1537. PMID 31948942
  51. Schmitt DL, Mehta S, Zhang J. Illuminating the kinome: visualizing real-time kinase activity in biological systems using genetically encoded fluorescent protein-based biosensors. Curr Opin Chem Biol. 2020; 54: 63-69. PMID 31911398
  52. Hertel F, Li S, Chen M, Pott L, Mehta S, Zhang J. Fluorescent biosensors for multiplexed imaging of phosphoinositide dynamics. ACS Chem Biol. 2020; 15(1): 33-38. PMID 31855412
  53. Ohadi D, Schmitt DL, Calabrese B, Halpain S, Zhang J, Rangamani P. Computational modeling reveals frequency modulation of calcium-cAMP/PKA pathway in dendritic spines. Biophys J. 2019; 117(10): 1963-1980. PMID: 31668749
  54. Qin Q, Laub S, Shi Y, Ouyang M, Peng Q, Zhang J, Wang Y, Lu. S. Fluocell for ratiometric and high-throughput live-cell image visualization and quantitation. Front Phys. 2019; 7: 00154. PMID 33163483
  55. Lin W, Mehta S, Zhang J. Genetically encoded fluorescent biosensors illuminate kinase signaling in cancer. J Biol Chem. 2019; 294(40): 14814-14822. PMID 31434714
  56. Clister T, Greenwald E, Baillie GS, and Zhang J. AKAP95 organizes a nuclear microdomain to control local cAMP and nuclear PKA activation. Cell Chem Biol. 2019; 26(6): 885-891.e4. PMID 30982750
  57. He M, Huang TS, Li S, Hong HC, Chen Z, Martin M, Zhou X, Huang HY, Su SH, Zhang J, Wang WT, Kang J, Huang HD, Zhang J, Chien S, Shyy JY. Atheroprotective flow upregulates ITPR3 (Inositol 1,4,5-Trisphosphate Receptor 3) in vascular endothelium via KLF4 (Krüppel-Like Factor 4)-mediated histone modifications. Arterioscler Thromb Vasc Biol. 2019; 39(5): 902-914. PMID 30917677
  58. Ross B, Wong SH, Snell NE, Zhang J, Rizzo MA. Triple fluorescence anisotropy reporter imaging in living cells. Bio-protocol. 2019; 9(9): e3226. PMID 31423459
  59. Qian Y, Piatkevich KD, Mc Larney B, Abdelfattah AS, Mehta S, Murdock MH, Gottschalk S, Molina RS, Zhang W, Chen Y, Wu J, Drobizhev M, Hughes TE, Zhang J, Schreiter ER, Shoham S, Razansky D, Boyden ES, Campbell RE. A genetically-encoded near-infrared fluorescent calcium ion indicator. Nat Methods. 2019; 16(2): 171-174. PMID 30664778
  60. Greenwald E, Mehta S, Zhang J. Genetically encoded fluorescent biosensors illuminate the spatiotemporal regulation of signaling networks. Chem Rev. 2018; 118 (24): 11707-11794. PMID 30550275
  61. Hard R, Li N, He W, Ross B, Mo GCH, Peng Q, Stein RL, Komives E, Wang Y, Zhang J, Wang W. Deciphering and engineering chromodomain-methyllysine peptide recognition. Sci Adv. 2018; 4(11): eaau1447. PMID 30417094
  62. Mehta S†*, Zhang Y*, Roth RH*, Zhang JF, Mo A, Tenner B, Huganir RL†, Zhang J†. Single-fluorophore biosensors for sensitive and multiplexed detection of signaling activities. *Equal contribution. †Co-corresponding authors. Nat Cell Biol. 2018; 20(10): 1215-1225. PMID 30250062
  63. Liu SL*, Wang ZG*, Hu Y, Xin Y, Singaram I, Gorai S, Zhou X, Shim Y, Min JH, Gong LW, Hay N, Zhang J, Cho W. Quantitative lipid imaging reveals a new signaling function of phosphatidylinositol-3,4-bisphophate: Isoform- and site-specific activation of Akt. *Equal contribution. Mol Cell. 2018; 71(6): 1092-1104. PMID 30174291
  64. Grimsey NJ, Narala R, Rada CC, Mehta S, Stephens BS, Kufareva I, Lapek J, Gonzalez DJ, Handel TM, Zhang J, Trejo J. A ryrosine switch on NEDD4-2 E3 ligase transmits GPCR inflammatory signaling. Cell Rep. 2018; 24(12): 3312-3323. PMID 30232011
  65. Ross BL, Tenner B, Markwardt ML, Zviman A, Shi G, Kerr JP, Snell NE, McFarland JJ, Mauban JR, Ward CW, Rizzo MA†, Zhang J†. Single-color, ratiometric biosensors for detecting signaling activities. †Co-corresponding authors. eLife. 2018; 7: e35458. PMID 29968564
  66. Chen W*, Yan Z*, Li S*, Huang N, Huang X, Zhang J†, Zhong S†. RNAs as proximity labeling media for identifying nuclear speckle positions relative to the genome. *Equal contribution. †Co-corresponding authors. iScience. 2018; 4: 204-215. PMID 30240742
  67. Oldach LM, Gorshkov K, Mills WT, Zhang J†, Meffert MK†. A biosensor for MAPK-dependent Lin28 signaling. †Co-corresponding authors. Mol Biol Cell. 2018; 29(10): 1157-1167. PMID 29540527
  68. Hertel F, Mo GCH, Dedecker P, Zhang J. Observing the assembly of protein complexes in living eukaryotic cells in super-resolution using refSOFI. Methods Mol Biol. 2018; 1764: 267-277. PMID 29605920
  69. Ni Q, Mehta S, Zhang J. Live-cell imaging of cell signaling using genetically encoded fluorescent reporters. FEBS J. 2018; 285(2): 203-219. PMID 28613457
  70. Chen Y, Booth C, Wang H, Wang RX, Terzi D, Zachariou V, Jiao K, Zhang J, Wang Q. Effective attenuation of adenosine A1R signaling by neurabin requires oligomerization of neurabin. Mol Pharmacol. 2017; 92(6): 630-639. PMID 28954816
  71. Mehta S and Zhang J. Illuminating the cell’s biochemical activity architecture. Biochemistry. 2017; 56(39): 5210-5213. PMID 28718621
  72. Nygren PJ, Mehta S, Schweppe DK, Langeberg LK, Whiting JL, Weisbrod CR, Bruce JE, Zhang J, Veesler D, Scott JD. Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and inhibitor drugs. eLife. 2017; 6: e30872. PMID 28967377
  73. Mo GCH, Ross B, Hertel F, Manna P, Yang X, Greenwald E, Booth C, Plummer AM, Tenner B, Chen Z, Wang Y, Kennedy EJ, Cole PA, Fleming KG, Palmer A, Jimenez R, Xiao J, Dedecker P, Zhang J. Genetically encoded biosensors for visualizing live-cell biochemical activity at superresolution. Nat Methods. 2017; 14(4): 427-434. PMID 28288122
  74. Gorshkov K, Mehta S, Ramamurthy S, Ronnett GV, Zhou FQ, Zhang J. AKAP-mediated feedback control of cAMP gradients in developing hippocampal neurons. Nat Chem Biol. 2017; 13(4): 425-431. PMID 28192412
  75. Rodriguez EA, Campbell RE, Lin JY, Lin MZ, Miyawaki A, Palmer AE, Shu X, Zhang J, Tsien RY. The growing and glowing toolbox of fluorescent and photoactive proteins. Trends Biochem Sci. 2017; 42(2): 111-129. PMID 27814948
  76. Newman RH and Zhang J. Integrated strategies to gain a systems-level view of dynamic signaling networks. Methods Enzymol. 2017; 589: 133-170. PMID 28336062
  77. Tenner B, Mehta S, Zhang J. Optical sensors to gain mechanistic insights into signaling assemblies. Curr Opin Struct Biol. 2016; 41: 203-210. PMID 27611602
  78. Zhou X, Li S, Zhang J. Tracking the activity of mTORC1 in living cells using genetically encoded FRET-based biosensor TORCAR. Curr Protoc Chem Biol. 2016; 8(4): 225-233. PMID 27925667
  79. Hung WC*, Yang JR*, Yankaskas CL, Wong BS, Wu PH, Pardo-Pastor C, Serra SA, Chiang MJ, Gu Z, Wirtz D, Valverde MA, Yang JT†, Zhang J†, Konstantopoulos K†. Confinement-sensing and signal optimization via Piezo1/PKA and Myosin II pathways. *Equal contribution. †Co-corresponding authors. Cell Rep. 2016; 15(7):1430-1441. PMID 27160899
  80. Moore BS, Stepanchick AN, Tewson PH, Hartle CM, Zhang J, Quinn AM, Hughes TE, Mirshahi T. Cilia have high cAMP levels that are inhibited by Sonic Hedgehog-regulated calcium dynamics. Proc Natl Acad Sci USA. 2016; 113(46): 13069-13074. PMID 27799542
  81. Conlon P, Gelin-Licht R, Ganesan A, Zhang J, Levchenko A. Single-cell dynamics and variability of MAPK activity in a yeast differentiation pathway. Proc Natl Acad Sci USA. 2016; 113(40): E5896-E5905. PMID 27651485
  82. Ross B, Mehta S, Zhang J. Molecular tools for acute spatiotemporal manipulation of signal transduction. Curr Opin Chem Biol. 2016; 34:135-142. PMID 27639090
  83. Hertel F, Mo GCH, Duwé S, Dedecker P, Zhang J. RefSOFI for mapping nanoscale organization of protein-protein interactions in living cells. Cell Rep. 2016; 14(2): 390-400. PMID 26748717
  84. Depry C, Mehta S, Li R, Zhang J. Visualization of compartmentalized kinase activity dynamics using adaptable bimKARs. Chem Biol. 2015; 22(11): 1470-9. PMID 26548610
  85. Mehta S and Zhang J. Dynamic visualization of calcium-dependent signaling in cellular microdomains. Cell Calcium. 2015. 58(4): 333-41. PMID 25703691
  86. Yaniv Y, Ganesan A, Yang D, Ziman BD, Lyashkov AE, Levchenko A, Zhang J, Lakatta EG. Real-time relationship between PKA biochemical signal network dynamics and increased action potential firing rate in heart pacemaker cells: kinetics of PKA activation in heart pacemaker cells. J Mol Cell Cardiol. 2015; 86: 168-78. PMID 26241846
  87. Hu J, Neiswinger J, Zhang J, Zhu H, Qian J. Systematic prediction of scaffold proteins reveals new design principles in scaffold-mediated signal transduction. PLoS Comput Biol. 2015; 11(9): e1004508. PMID 26393507
  88. Sample V, Ramamurthy S, Gorshkov K, Ronnett GV, Zhang J. Polarized activities of AMPK and BRSK in primary hippocampal neurons. Mol Biol Cell. 2015; 26(10): 1935-1946. PMID 25788287
  89. Karlsson I, Zhou X, Thomas R, Smith AT, Bonner MY, Bakshi P, Banga AK, Bowen JP, Qabaja G, Ford SL, Ballard MD, Petersen KS, Li X, Chen G, Ogretmen B, Zhang J, Watkins EB, Arnold RS, Arbiser JL. Solenopsin A and analogs exhibit ceramide-like biological activity. Vasc Cell. 2015; 7: 5. PMID 26015865
  90. Miyamoto T†, Rho E, Sample V, Akano H, Magari M, Ueno T, Gorshkov K, Chen M, Tokumitsu H, Zhang J†, Inoue T†. Compartmentalized AMPK signaling illuminated by genetically encoded molecular sensors and actuators. †Co-corresponding authors. Cell Rep. 2015; 11(4): 657-670. PMID 25892241
  91. Ding Y, Li J, Enterina JR, Shen Y, Zhang I, Tewson PH, Mo GCH, Zhang J, Quinn AM, Hughes TE, Maysinger D, Alford SC, Zhang Y, Campbell RE. Ratiometric biosensors based on dimerization-dependent fluorescent protein exchange. Nat Methods. 2015; 12(3): 195-198. PMID 25622108
  92. Zhou X, Clister TL, Lowry PR, Seldin MM, Wong GW, Zhang J. Dynamic visualization of mTORC1 activity in living cells. Cell Rep. 2015; 10(10): 1767-1777. PMID 25772363
  93. Clister T, Mehta S, and Zhang J. Single-cell analysis of G-protein signal transduction. J Biol Chem. 2015; 290(11): 6681-6688. PMID 25605723
  94. Dou H, Wang C, Wu X, Yao L, Zhang X, Teng S, Xu H, Liu B, Wu Q, Zhang Q, Hu M, Wang Y, Wang L, Wu Y, Shang S, Kang X, Zheng L, Zhang J, Raoux M, Lang J, Li Q, Su J, Yu X, Chen L, Zhou Z. Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells. Diabetologia. 2015; 58(2): 324-233. PMID 25381556
  95. Weng HJ, Patel KN, Jeske NA, Bierbower SM, Zou W, Tiwari V, Zheng Q, Tang Z, Mo GCH, Wang Y, Geng Y, Zhang J, Guan Y, Akopian AN, Dong X. Tmem100 is a regulator of TRPA1-TRPV1 complex and contributes to persistent pain. Neuron. 2015; 85(4): 833-846. PMID 25640077
  96. Gorshkov K and Zhang J. Visualization of cyclic nucleotide dynamics in neurons. Front Cell Neurosci. 2014; 8: 395. PMID 25538560
  97. Newman RH, Zhang J, Zhu H. Toward a systems-level view of dynamic phosphorylation networks. Front Genet. 2014; 5: 263. PMID 25177341
  98. Mehta S, Aye-Han NN, Ganesan A, Oldach L, Gorshkov K, Zhang J. Calmodulin-controlled spatial decoding of oscillatory Ca2+ signals by calcineurin. eLife. 2014; 3: e03865. PMID 25056880
  99. Fu Q, Kim S, Soto D, De Arcangelis V, Dipilato L, Liu S, Xu B, Zhang J, Shi Q, Xiang YK. A long lasting β1 adrenergic receptor stimulation of cAMP/protein kinase A (PKA) signal in cardiac myocytes. J Biol Chem. 2014; 289(21): 14771-14781. PMID 24713698
  100. Haj Slimane Z, Bedioune I, Lechêne P, Varin A, Lefebvre F, Mateo P, Domergue-Dupont V, Dewenter M, Richter W, Conti M, El-Armouche A, Zhang J, Fischmeister R, Vandecasteele G. Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes. Cardiovasc Res. 2014; 102(1): 97-106. PMID 24550350
  101. Wang Y, Ho TG, Bertinetti D, Neddermann M, Franz E, Mo GCH, Schendowich LP, Sukhu A, Spelts RC, Zhang J, Herberg FW, Kennedy EJ. Isoform-selective disruption of AKAP-localized PKA using hydrocarbon stapled peptides. ACS Chem Biol. 2014; 9(3): 635-642. PMID 24422448
  102. Sample V, Mehta S, Zhang J. Genetically encoded molecular probes to visualize and perturb signaling dynamics in living biological systems. J Cell Sci. 2014; 127(Pt 6): 1151-1160. PMID 24634506
  103. Cazabat L, Ragazzon B, Varin A, Potier-Cartereau M, Vandier C, Vezzosi D, Risk-Rabin M, Guellich A, Schittl J, Lechêne P, Richter W, Nikolaev VO, Zhang J, Bertherat J, Vandecasteele G. Inactivation of the Carney complex gene 1 (PRKAR1A) alters spatiotemporal regulation of cAMP and cAMP-dependent protein kinase: a study using genetically-encoded FRET-based reporters. Human Mol Genet. 2014; 23(5): 1163-74. PMID 24122441
  104. Hertel F and Zhang J. Monitoring of post-translational modification dynamics with genetically encoded fluorescent reporters. Biopolymers. 2014; 101(2): 180-187. PMID 23576192
  105. Oldach L and Zhang J. Genetically encoded fluorescent biosensors for live-cell visualization of protein phosphorylation. Chem Biol. 2014; 21(2): 186-197. PMID 24485761
  106. Hu J*, Rho HS*, Newman RH*, Hwang W, Neiswinger J, Zhu H†, Zhang J†, Qian J†. Global analysis of phosphorylation networks in humans. *Equal contribution. †Co-corresponding authors. Biochim Biophys Acta. 2014; 1844(1 Pt B): 224-231. PMID 23524292
  107. Hu J, Rho HS, Newman RH, Zhang J, Zhu H, Qian J. PhosphoNetworks: a database for human phosphorylation networks. Bioinformatics. 2014; 30(1): 141-142. PMID 24227675
  108. Robinson KH, Yang JR, Zhang J. FRET and BRET-based biosensors in live cell compound screens. Methods Mol Biol. 2014; 1071: 217-225. PMID 24052392
  109. Aye-Han NH and Zhang J. Multi-parameter live cell imaging approach to monitor cyclic AMP and protein kinase A dynamics in parallel. Methods Mol Biol. 2014; 1071: 207-215. PMID 24052391
  110. Mehta S and Zhang J. Using a genetically encoded FRET-based reporter to visualize calcineurin phosphatase activity in living cells. Methods Mol Biol. 2014; 1071: 139-149. PMID 24052386
  111. Newman RH and Zhang J. The design and application of genetically encodable biosensors based on fluorescent proteins. Methods Mol Biol. 2014; 1071: 1-16. PMID 24052376
  112. Burdyga A, Conant A, Haynes L, Zhang J, Jalink K, Sutton R, Neoptolemos J, Costello E, Tepikin A. cAMP inhibits migration, ruffling and paxillin accumulation in focal adhesions of pancreatic ductal adenocarcinoma cells: Effects of PKA and EPAC. Biochim Biophys Acta. 2013; 1833(12): 2664-2672. PMID 23797058
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  157. Rahdar M, Inoue T, Meyer T, Zhang J, Vazquez F, Devreotes PN. A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proc Natl Acad Sci USA. 2009; 106(2): 480-485. PMID 19114656
  158. Ren YR, Pan F, Parvez S, Fleig A, Chong CR, Xu J, Dang Y, Zhang J, Jiang H, Penner R, Liu JO. Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes. PLoS One. 2008; 3(12): e4009. PMID 19104661
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  171. Maresh J, Zhang J, Tzeng YL, Goodman NA, Lynn DG. Rational design of inhibitors of VirA-VirG two-component signal transduction. Bioorg Med Chem Lett. 2007; 17: 3281-3286. PMID 17470391
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  178. Maresh J*, Zhang J*, Lynn DG. The Innate Immunity of maize and the dynamic chemical strategies tegulating two-component signal transduction in Agrobacterium tumefaciens. *Equal contribution. ACS Chem Biol. 2006; 1(3): 165-175. PMID 17163664
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  187. Zhang J, Boone L, Kocz R, Zhang C, Binns AN, Lynn DG. At the maize/Agrobacterium interface: natural factors limiting host transformation. Chem Biol. 2000; 7(8): 611-621. PMID 11048952
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